Hyperthermia is a type of treatment in which body tissue is exposed to high temperatures (up to 113ºF), to damage and kill cancer cells, or to make cancer cells more sensitive to the effects of radiation and certain anticancer drugs. Local hyperthermia treatment (heat applied to a very small area, such as a tumor) is a well-established cancer treatment method with a simple basic principle: If a rise in temperature to 106ºF can be obtained for one hour within a cancer tumor, the cancer cells will be destroyed. Primary malignant tumors have a bad blood circulation, which make them more sensitive to changes in temperature.

In local hyperthermia, heat is applied to a small area, such as a tumor, using various techniques that deliver energy to heat the tumor. Different types of energy may be used to apply heat, including microwave, radiofrequency, and ultrasound. Depending on the tumor location, there are several approaches to local hyperthermia:

CANCER FACTS National Cancer Institute National Institutes of Health Hyperthermia, a procedure in which body tissue is exposed to high temperatures (up to 113 F), is under investigation to assess its effectiveness in the treatment of cancer. Scientists think that heat may help shrink tumors by damaging cells or depriving them of substances they need to live. They are studying local, regional, and whole-body hyperthermia, using external and internal heating devices. Hyperthermia is almost always used with other forms of therapy (radiation therapy, chemotherapy, and biological therapy) to try to increase their effectiveness.

Local hyperthermia refers to heat that is applied to a very small area, such as a tumor. The area may be heated externally with high-frequency waves aimed at a tumor from a device outside the body. To achieve internal heating, one of several types of sterile probes may be used, including thin, heated wires or hollow tubes filled with warm water; implanted microwave antennae; and radiofrequency electrodes.


Hyperthermia means an abnormally high body temperature. It is thought that heating areas of the body that contain a cancer, or heating the tumour itself, may help to kill cancer cells. This treatment exposes the body tissue to high temperatures, between 40°-45°C (104º-113ºF), without harming surrounding healthy tissue. The normal body temperature is 37°C (98.6 ºF).

Hyperthermia treatment is mostly used to treat cancer that is localised in one part of the body. Giving hyperthermia treatment in combination with chemotherapy drugs or radiotherapy, or with both, may help to improve the effect of these treatments.

At the moment hyperthermia treatment is not available in the UK. It is available in Europe however, and a small number of patients in the UK may be able to have this treatment abroad through the NHS. Hyperthermia is suitable for breast cancer that has come back in the breast area (local recurrence).


Hyperthermia treatment destroys cancer cells by raising the tumour temperature. This is similar to the way the body uses fever to fight infection. When normal body tissue is heated the blood vessels open up (dilate) to allow the blood to flow more freely. This helps to cool down the area and prevent damage. The blood supply to cancer cells is different. The blood vessels cannot dilate as well and blood flow is generally slower. When heat is applied to a cancer, the cells are less able to cool down and are more likely to be damaged by the high temperature. The effect of the heat damages to the cancer cells and can deprive them of the nutrients they need to survive.

Hyperthermia treatment is almost always used in combination with either radiotherapy or chemotherapy.


How the treatment is given, and how much treatment is needed, depends on a number of factors. These include the part of the body affected by cancer and the size and shape of the tumour.

There are three ways in which hyperthermia can be given, depending on how much of the body needs treatment. These are known as local, regional and whole body hyperthermia. This information discusses local hyperthermia. If you would like information about regional or whole body hyperthermia, please contact our cancer support service nurses.


In local hyperthermia treatment, heat is applied to a small area only. This is done using applicators that are placed close to, or in, the tumour. There are different ways to deliver local hyperthermia: external; intraluminal (also called endocavitary); and interstitial. The method used depends on the type and position of the tumour.


This is the technique that is used to treat breast cancer. It is also used for cancers that are on, or just below, the skin. The tumour is heated externally using applicators that are placed on, or near to, the affected area. Heat is then applied using high-frequency energy waves generated from a device outside the body (such as a microwave or ultrasound).


This may be used to treat cancers that are within or near to body cavities, such as the gullet (oesophagus) or rectum. A sterile probe that can be heated (a thin wire or hollow tube filled with water) is placed inside the cavity where the tumour is. This heats the affected area. Interstitial hyperthermia This is used to treat tumours which are deep within the body, such as brain tumours. Under anaesthetic, probes or wires are placed within the tumour tissue and then heated. This method allows tumours to be heated to a higher temperature than external techniques.


You will lie on a bed or treatment couch and have a local anaesthetic to numb the area. Temperature monitors are applied to the area around the tumour. Thin plastic tubes (catheters) are then inserted into the tumour and instruments which regulate temperature are placed inside the catheters.

A water bag is placed on the area to be treated to keep the skin cool. The applicator (a small metal box which contains microwave radiators) is placed on the water bag. You will be awake during the procedure and asked to remain fairly still. During the treatment, members of staff are always nearby and will come and make adjustments to the position of the applicator. Each treatment can take up to an hour and a half.

During treatment, the staff will aim to get the temperature in the tumour as high as possible without damaging nearby tissues. The temperature will be measured continually and will be increased as long as you are comfortable. If you feel symptoms such as a burning sensation or a feeling of pressure on the area being treated, it is important you tell a member of staff. It may be that the temperature is too high and needs adjusting.

You might find that your whole body temperature starts to increase during treatment. You will be kept as comfortable as possible with air conditioning, wet towels, a cold water bag close to your neck and extra ventilation.

During the treatment your blood pressure and heart rate are monitored regularly and your temperature will be monitored from time to time. You can have a relative or friend with you in the room during the procedure. If your companion has a pacemaker or is pregnant, however, they are not allowed to stay in the treatment room.


Generally hyperthermia treatment is tolerated well with few side effects or complications.

During treatment you may feel a sensation of heat (like a hot water bottle). Heat applied directly to the skin can cause discomfort. It can also cause blisters, which usually heal within 2-5 days.

Increasing the temperature of the treatment may cause the skin to burn or may cause muscle tenderness. The burn might result in a firm, tender spot below the skin. It will heal and usually the tenderness will disappear within a few days. This may cause problems, however, if you need further hyperthermia treatment. Often people feel very tired after treatment. Usually the tiredness disappears after a few hours or following a night's sleep.


1. Cancer back up. Com
2. Cancercenter.com
3. National Cancer Institute.com
4. Biotherapy Journal.com
5. Indiba.com